Singer John Mayer Diagnosed with Vocal Cord Granuloma

On Sept 19, 2011, media reported that singer John Mayer has been forced to cancel all upcoming concert plans and delay release of a new album due to a voicebox growth.

This growth was described as a "granuloma."

What exactly is a granuloma?

It is a benign mass commonly due to repetitive mild vocal trauma resulting in exuberant growth of a specific region of the voicebox lining.

To be more precise, rather than the vocal cord itself, granulomas are most commonly found on the vocal process which is the "hinge" that allows for vocal cord movement. It is located in the back area of the voicebox.

An imprecise analogy of what a granuloma is would be a keloid of the skin.

Symptoms include mild (if any) hoarseness, mild intermittent pain on the side of the voicebox where the granuloma is located with talking/singing, rarely coughing up blood, and if large, shortness of breath.

Just like keloids of the skin, surgical removal alone is almost certainly going to fail with recurrence of the granuloma within weeks to months. All repetitive trauma to the area must be addressed to minimize risk of recurrence which is why restricted voice use must be pursued for several months (no loud talking/singing, talking ONLY when you must). Voice therapy helps to "teach" a person how to talk when they talk without causing further injury to the area. As such, botox injection to the vocal cord has been found helpful to semi-paralyze the vocal cords from coming together (chemically induced vocal cord paralysis). Reflux medications are necessary even if a patient has no symptoms as ANY acid exposure to the area is just as bad a trauma due to yelling.

Steroid injections are helpful to minimize the underlying exuberant inflammatory reaction that leads to granuloma recurrence and may need to be performed several times for effect.

To summarize, the steps followed when a granuloma-like mass is discovered on exam is as follows:

1) Trial restricted voice use and reflux medications. Voice therapy also strongly recommended.
2) If no improvement after a period of time, surgical excision to ensure it truly is a granuloma and not cancer or some other pathology
3) Follow-up with steroid injections to the granuloma site. Watch video below.
4) Botox injection can be considered which chemically prevents complete vocal cord adduction preventing the repetitive trauma to the granuloma site.

Read a Rolling Stone report here.

Read more about voicebox granulomas.

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New Webpage on Facial Paralysis

Our office has produced a new webpage on the evaluation and management of facial paralysis without any other symptoms.

Click here to read more about this condition.

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Major League Baseball Bans Under the Tongue Deer Antler Spray Use

On Aug 6, 2011, ESPN reported that MLB players have been issued a warning regarding use of Deer Antler spray administered under the tongue.

Deer-Antler spray contains "potentially contaminated nutritional supplements" along with IGF-1 (Insulin Growth Factor) which players have used in the past as an alternative to steroids, especially given it can't be detected in urine samples (only blood testing).

What's with Deer-Antler spray specifically? Scientists discovered IGF-1 in the velvet of immature deer antlers and IGF-1 is considered a performance-enhancer that mediates the level of human growth hormone in the body.

Why under the tongue (sublingual administration)? Because the mucus membrane is quite thin under the tongue richly underlaid with capillary blood vessels allowing for direct diffusion of the substance directly into the body's bloodstream with little or no alteration. This process takes less than a minute to occur. This is in contrast to swallowing a pill which gets digested in the stomach with acid, further digested in the intestines with enzymes, absorbed into the hepatic circulation where further degradation occurs in the liver before getting into general body circulation for effect. A 30-60 minute process.

That's why sublingual nitrogen is such a potent medication to treat chest pain due to an impending heart attack. It works FAST!

It's another reason why sublingual immunotherapy otherwise known as allergy drops is a growing acceptable alternative to allergy shots to try and cure allergies.

Read the ESPN story here.

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Steroid and Anti-Histamine All-In-One Nasal Spray!

Meda Pharmaceuticals has announced a new nasal spray "Dymista" that contains both a steroid and an anti-histamine active ingredient. Why is this significant? It's because it's the first and only one to do so. Of course, it's not available yet until the FDA approves it, but at least it has shown effectiveness in Phase 3 clinical trials.

At this time, nasal sprays as it relates to nasal allergies come in two separate flavors:

1) Steroid Nasal Spray (flonase, nasonex, nasacort, rhinocort, veramyst, omnaris, etc, etc)
2) Anti-Histamine Nasal Spray (patanase, astepro, astelin)

This new combo nasal spray "Dymista" contains fluticasone and azelastine. Fluticasone is a steroid that is also found in flonase nasal spray whereas azelastine is an anti-histamine also found in astepro and astelin nasal sprays.

Clinical trials in the past have shown that using a steroid nasal spray and an anti-histamine nasal spray was more effective than using one or the other individually.

Similarly, Dymista has also been found to be better than either nasal spray alone, but with the convenience of using a single nasal spray.

Look for it in the near future! Let's just hope insurance will cover it however.

Read the press release here.

Reference:
Onset of Action of MP29-02 in the Treatment of Seasonal Allergic Rhinitis. J Allergy Clin Immunol 2011; 127; 2; Abstracts 199

MP29-02 in the Treatment of Nasal Symptoms of Seasonal Allergic Rhinitis. J Allergy Clin Immunol 2011; 127; 2; Abstracts 199

Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis. Annals of Allergy, Asthma and Immunology, 2008, vol. 100, no. 1, pp. 74 - 81.

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Steroid Inhalers for Asthma Can Cause Fungal Laryngitis

It is a big bummer to be an asthmatic. Not only is breathing a problem, but even the treatment for asthma can cause problems.

Take for example steroid inhalers like advair, symbicort, fluticasone, etc.

All asthma patients know to rinse their mouth out after inhaler use due to risk of oral thrush, but what about from the back of the mouth down to the vocal cords??? This nether region can't be gargled very easily. One can swallow water to rinse this area out, but the vocal cord region would still not be addressed (otherwise aspiration would occur).

And that leads to potential vocal problems... like fungal laryngitis (or thrush of the voicebox). Here's a picture of what that looks like. To compare, normal is shown in the smaller picture.

Note the white patches indicative of fungal growth. This fungal infection can lead to symptoms of a mild (if any) sore throat, but most patients complain of hoarseness as their only symptom.

Treatment is ideally to stop the steroid inhaler triggering the infection, but if an asthmatic needs it... than they need it. As I often tell patients, breathing is more important than voice. Often, anti-fungal medications like diflucan and nystatin can eliminate the fungal laryngitis, but problem is, as long as steroid inhalers are used, it comes right back. And repetitive anti-fungal treatment can place the patient at risk for a drug-resistant fungal infection.

So what to do???

There is one type of little-known (unpleasant) treatment an asthmatic patient can perform to minimize risk of fungal laryngitis while still maintaining steroid inhaler use.

It's called laryngeal washes and it takes a lot of time, patience, and period of discomfort. Think of it as gargling of the voicebox.

The patient takes a curved luer-lock cannula (picture shown) attached to a syringe filled with salt-water. While opening the mouth and sticking the tongue out, the curved end of the cannula is directed such that the end is pointed straight down into the throat. After taking a deep breath in, while saying "ah", salt-water is dripped down into the throat thereby "gargling" the voicebox. Coughing may be inevitable after performing.

This needs to be done after every steroid inhaler use. Or during an active fungal infection, at least 4 times per day.

Gagging is the biggest problem preventing correct usage of this technique. Coordinating the injection while saying "ah" is another issue since if it is incorrectly performed, can lead to aspiration and severe coughing. As such, it is not for everyone.

One can purchase such "luer-lock laryngeal cannulas" from any ENT medical supply company.

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Study Suggests (Incorrectly?) Steroid Nasal Spray Use Does Not Help with Eustachian Tube Dysfunction

In the May 2011 edition of Archives of Otolaryngology-Head & Neck Surgery, a study was published on a randomized, placebo-controlled, double-blind prospective clinical trial (the best kind of research) to determine whether Nasacort AQ steroid nasal spray can resolve eustachian tube dysfunction as well as ear symptoms related to this disorder. Eustachian tube dysfunction at its mildest would cause symptoms of ear clogging much akin to the way the ears fill up when flying or driving up the mountain. At its worst, can lead to fluid buildup in the ear as well as chronic ear infections.

In the study population of 91 patients, they found that use of a steroid nasal spray did NOT help...

HOWEVER, after reading the paper, there is a major flaw to how the study was conducted which would significantly affect study outcomes. Mainly, how the nasal spray is used would strongly affect whether it will help or not.

According to the paper, patients were instructed to simply administer "2 metered sprays in each nostril once daily (55 µg per spray)..."

Nothing else.

Unfortunately, this type of administration is bound to fail, mainly because using a nasal spray in this manner is inadequate when addressing eustachian tube dysfunction.

First of all, the eustachian tube openings are at 90 degrees to the face, so the steroid nasal spray bottle needs to be directed towards the back of the head and not towards the eye. This needs to be specifically mentioned/demonstrated as it is not intuitive for most patients (and even doctors). The first picture is INCORRECT! The second picture is correct use. Read more here why directionality is important.

Second, a valsalva maneuver (blow air out the nose while keeping the nares pinched) must be performed after nasal spray administration in order to force the nasal spray medicine up into the eustachian tubes in order for the medication to affect the region of concern. Without a valsalva, the nasal spray medicine sits in the nasal cavity which would help with sinus problems, but not the ears which is the area of complaint. Valsalva needs to be done regularly throughout the day during treatment.

Why is this maneuver important? It's like pouring draino (steroid nasal spray) into a clogged toilet, but than not using a plunger (valsalva maneuver).

In any case, there are other studies that have found steroid nasal sprays to be helpful for eustachian tube dysfunction as listed under references.

Read more about eustachian tube dysfunction here.

References:
Management of Eustachian Tube Dysfunction With Nasal Steroid Spray. Arch Otolaryngol Head Neck Surg. 2011;137(5):449-455. doi:10.1001/archoto.2011.56

The role of topical nasal steroids in the treatment of children with otitis media with effusion and/or adenoid hypertrophy. Int J Pediatr Otorhinolaryngol. 2006;70(4):639-645.

Oral or topical nasal steroids for hearing loss associated with otitis media with effusion in children. Cochrane Database Syst Rev. 2006 Jul 19;3:CD001935.

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Generic Nasacort AQ Will Be Available June 15, 2011

A generic version of Nasacort AQ will be available on June 15, 2011.

Nasacort AQ is an aqueous steroid nasal spray in the treatment of allergies. Currently, flonase (fluticasone) is the only generic steroid nasal spray available.

As such, the company has stopped sampling Nasacort AQ for many physician offices including ours.

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Singulair May Help Reduce Tonsil and Adenoid Enlargement

Singulair is a medication often prescribed for asthma as well as allergies and works by blocking the leukotriene receptor. This mechanism is different than that found in common allergy medications like claritin and benadryl which work by blocking the histamine receptor (anti-histamine).

Singulair has also incidentally been found to possibly help reduce the size of tonsils and adenoids. Given this beneficial affect, singulair may be a helpful intervention in those kids with mild obstructive sleep apnea or nasal obstruction due to adenoid hypertrophy avoid surgical intervention (tonsillectomy and adenoidectomy).

Steroid nasal sprays have also been found helpful to reduce adenoid size.

However, only an association between singulair use and reduction in adenoid/tonsil size has been found. Double-blind, placebo-controlled studies are required for determination of true benefit.

Singulair can be given from the age of 1 year old.

References:
Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med. 2005 Aug 1;172(3):364-70. Epub 2005 May 5.

Leukotriene pathways and in vitro adenotonsillar cell proliferation in children with obstructive sleep apnea. Chest. 2009 May;135(5):1142-9. Epub 2008 Dec 31.

The role of mometasone furoate aqueous nasal spray in the treatment of adenoidal hypertrophy in the pediatric age group: preliminary results of a prospective, randomized study. Pediatrics. 2007 Jun;119(6):e1392-7. Epub 2007 May 28.

Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy. Cochrane Database Syst Rev. 2008 Jul 16;(3):CD006286.

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New Video Created on Intra-Tympanic Steroid Injection for Sudden Hearing Loss

A new video has been uploaded to our office's YouTube Channel on Intra-Tympanic Steroid Injection used to treat patients who suffer sudden sensorineural hearing loss. The steroid injection is usually with decadron, though other types of steroids including methylprednisolone has been used.

Watch the video here on YouTube or below.

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